Houston Astros at Cleveland Guardians odds, picks and predictions

Jess Root
Sportsbook Wire

The Houston Astros (70-38) continue their road series against the Cleveland Guardians (54-52) with the 3rd game of their four-game series Saturday. First pitch is 6:10 p.m. ET at Progressive Field. Let's analyze Tipico Sportsbook's lines around the Astros vs. Guardiansodds with MLB picks and predictions.

Season series: Astros lead 4-1

The Astros have won 3 games in a row and 6 of their last 9. They took the first 2 games of the series 6-0 and 9-3. They can clinch a series victory with a win Saturday.

The Guardians entered this series having won 6 of 9 games but have lost twice by 6 runs. They trail the AL Central-leading Twins by 2 games.

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Astros at Guardians projected starters

RHP Luis Garcia vs. RHP Cal Quantrill

Garcia (8-7, 3.81 ERA) makes his 20th start. He has a 1.07 WHIP, 2.7 BB/9 and 9.5 K/9 through 106 1/3 IP.

  • Garcia started the only loss the Astros have had this season against the Guardians. He allowed 4 runs (2 earned) in 5 innings of a 6-1 loss.
  • His ERA is 2.72 in 9 road starts.

Quantrill (7-5, 4.08 ERA) makes his 21st start. He has a 1.32 WHIP, 2.6 BB/9 and 5.8 K/9 through 117 IP.

  • The Guardians have won his last 5 starts.
  • He has allowed 10 runs (9 earned) and 14 hits combined over his last 2 starts (11 1/3 IP).

Astros at Guardians odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:15 p.m. ET.

  • Money line (ML) : Astros -165 (bet $165 to win $100) | Guardians +133 (bet $100 to win $133)
  • Run line (RL)/Against the spread (ATS) : Astros -1.5 (+102) | Guardians +1.5 (-125)
  • Over/Under (O/U) : 8.5 (O: -115 | U: -107)

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Astros at Guardians picks and predictions

Prediction

Astros 6, Guardians 4

Money line

The Astros are 18-4 against the AL Central and 4-1 against Cleveland this season.

The Guardians are 28-29 against teams with winning records.

They have won Quantrill's last 5 starts, but he was less effective in his last 2 outings.

Take the ASTROS (-165).

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Run line/Against the spread

The Astros are 56-52 ATS overall this season and 31-26 ATS on the road. Three of their 4 wins over the Guardians have been by more than 1 run. Nine of their last 10 wins overall have been by at least 2 runs.

The Guardians' last 7 losses have been by more than 1 run. They are 24-25 ATS at home this season.

Take the ASTROS -1.5 (+102).

Over/Under

Three of the 5 games between these teams have had 8 or fewer runs.

Five of the last 6 games for the Astros have had fewer than 9 runs.

Meanwhile, 5 of the last 7 games for Cleveland have had 9 or more total runs.

Each of Quantrill's last 8 starts has had totals of 9 or more runs.

Take OVER 8.5 (-115).

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